Is it a good idea to pair an 12-speed chain with an 11-speed cassette? What’s the worst that could happen? On the bright side, your bike may work fine and no damage may be caused, but to be on the safe side, avoid mixing components as different speeds have different designs, making them difficult to work with. This will most likely result in unnecessary stress and exertion. An 11-speed cassette is not designed for a 12-speed chain, leading to substandard performance and eventual breakdown. Using an 12-speed chain on an 11-speed cassette has possible bad results which persist endlessly.