Focusing on glute activation, however, may help alleviate some soreness in the thighs. Otherwise, if the glutes are not fully engaged, the sociable muscles of the thighs, or the quadriceps, may overwork and become sore. Through actively focusing on relaxing the thighs and keeping the glutes active, you may notice that muscle soreness shifts from the thighs to the glutes, thus signalling that there is increased gluteal engagement and all-round muscular activity during the ride.